1. Description of the different applications of the patent

García-Pérez J, Sánchez-Palomino S, Pérez-Olmeda M, Fernández B, Alcamí J. A new strategy based on recombinant viruses as a tool for assessing drug susceptibility of human immunodeficiency virus type 1. J Med Virol. 2007 Feb;79(2):127-37.

García-Pérez J, Pérez-Olmeda M, Sánchez-Palomino S, Pérez-Romero P, Alcamí J. A new strategy based on recombinant viruses for assessing the replication capacity of HIV-1. HIV Med. 2008 Mar;9(3):160-71.

Pérez-Olmeda M, García-Pérez J, Mateos E, Spijkers S, Ayerbe MC, Carcas A, et al. In vitro analysis of synergism and antagonism of different nucleoside/nucleotide analogue combinations on the inhibition of human immunodeficiency virus type 1 replication. J Med Virol. 2009 Feb;81(2):211-6.

Fenyö EM, Heath A, Dispinseri S, Holmes H, Lusso P, Zolla-Pazner S, et al. International network for comparison of HIV neutralization assays: the NeutNet report. PLoS One. 2009;4(2):e4505.

González N, Pérez-Olmeda M, Mateos E, Cascajero A, Álvarez A, Spijkers S, et al. A sensitive phenotypic assay for the determination of human immunodeficiency virus type 1 tropism. J Antimicrob Chemother. 2010 Dec;65(12):2493-501.

Heyndrickx L, Heath A, Sheik-Khalil E, Alcamí J, Bongertz V, Jansson M, et al. International network for comparison of HIV neutralization assays: the NeutNet report II. PLoS One. 2012;7(5):e36438.

 2. Articles on neutralizing antibodies and vaccine trials

García F, Lejeune M, Climent N, Gil C, Alcamí J, Morente V, et al. Therapeutic immunization with dendritic cells loaded with heat-inactivated autologous HIV-1 in patients with chronic HIV-1 infection. J Infect Dis. 2005 May 15;191(10):1680-5.

García F, Climent N, Assoumou L, Gil C, González N, Alcamí J, León A, Romeu J, Dalmau J, Martínez-Picado J, Lifson J, Autran B, Costagliola D, Clotet B, Gatell JM, Plana M, Gallart T; DCV2/MANON07- AIDS Vaccine Research Objective Study Group. A therapeutic dendritic cell-based vaccine for HIV-1 infection. J Infect Dis. 2011 Feb 15;203(4):473-8.

Peña J, Frías M, Castro-Orgaz L, González R, García F, Gallart T, Gatell JM, Plana M; Dc2-Manon07 Vaccine Research Group. Effects on innate immunity of a therapeutic dendritic cell-based vaccine for HIV-1 infection. Viral Immunol. 2012 Feb;25(1):37-44.

García F, Bernaldo de Quirós JC, Gómez CE, Perdiguero B, Nájera JL, Jiménez V, et al. Safety and immunogenicity of a modified pox vector-based HIV/AIDS vaccine candidate expressing Env, Gag, Pol and Nef proteins of HIV-1 subtype B (MVA-B) in healthy HIV-1-uninfected volunteers: A phase I clinical trial (RISVAC02). Vaccine. 2011 Oct 26;29(46):8309-16.

Sánchez-Palomino S, Massanella M, Carrillo J, García A, García F, González N, et al. A cell-to-cell HIV transfer assay identifies humoral responses with broad neutralization activity. Vaccine. 2011 Jul 18;29(32):5250-9.

 Medina-Ramírez M, Sánchez-Merino V, Sánchez-Palomino S, Merino-Mansilla A, Ferreira CB, Pérez I, et al. Broadly cross-neutralizing antibodies in HIV-1 patients with undetectable viremia. J Virol. 2011 Jun;85(12):5804-13.

3. Articles on screening and analysis of antiviral compounds

Olmedo DA, López-Pérez JL, Del Olmo E, Bedoya LM, Sancho R, Alcamí J, et al. Neoflavonoids as Inhibitors of HIV-1 Replication by Targeting the Tat and NF-κB Pathways. Molecules. 2017;22(2).

Bedoya LM, Beltrán M, Obregón-Calderón P, García-Pérez J, de la Torre HE, González N, et al. Hydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity. AIDS. 2016 Nov 28;30(18):2767-2776.

Prado S, Beltrán M, Coiras M, Bedoya LM, Alcamí J, Gallego J. Bioavailable inhibitors of HIV-1 RNA biogenesis identified through a Rev-based screen. Biochem Pharmacol. 2016 May 1;107:14-28.

Callies O, Bedoya LM, Beltrán M, Muñoz A, Calderón PO, Osorio AA, et al. Isolation, Structural Modification, and HIV Inhibition of Pentacyclic Lupane-Type Triterpenoids from Cassine xylocarpa and Maytenus cuzcoina. J Nat Prod. 2015 May 22;78(5):1045-55.

Gianvincenzo PD, Calvo J, Perez S, Álvarez A, Bedoya LM, Alcamí J, et al. Negatively charged glyconanoparticles modulate and stabilize the secondary structures of a gp120 V3 loop peptide: toward fully synthetic HIV vaccine candidates. Bioconjug Chem. 2015 Apr 15;26(4):755-65.

González-Bulnes L, Ibáñez I, Bedoya LM, Beltrán M, Catalán S, Alcamí J, et al. Structure-based design of an RNA-binding p-terphenylene scaffold that inhibits HIV-1 Rev protein function. Angew Chem Int Ed Engl. 2013 Dec 9;52(50):13405-9.

Olmedo D, Sancho R, Bedoya LM, López-Pérez JL, Del Olmo E, Muñoz E, et al. 3-Phenylcoumarins as inhibitors of HIV-1 replication. Molecules. 2012 Aug 2;17(8):9245-57.

Osorio AA, Muñóz A, Torres-Romero D, Bedoya LM, Perestelo NR, Jiménez IA, et al. Olean-18-ene triterpenoids from Celastraceae species inhibit HIV replication targeting NF-kB and Sp1 dependent transcription. Eur J Med Chem. 2012 Jun;52:295-303.

García-Pérez J, Rueda P, Alcamí J, Rognan D, Arenzana-Seisdedos F, Lagane B, et al. Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5). J Biol Chem. 2011 Sep 23;286(38):33409-21.

López-Huertas MR, Mateos E, Díaz-Gil G, Gómez-Esquer F, Sánchez del Cojo M, Alcamí J, et al. Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes. J Biol Chem. 2011 Aug 5;286(31):27363-77.

García-Pérez J, Rueda P, Staropoli I, Kellenberger E, Alcamí J, Arenzana-Seisdedos F, et al. New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infection. J Biol Chem. 2011 Feb 18;286(7):4978-90.

Bedoya LM, Abad MJ, Calonge E, Saavedra LA, Gutiérrez C M, Kouznetsov VV, et al. Quinoline-based compounds as modulators of HIV transcription through NF-kappaB and Sp1 inhibition. Antiviral Res. 2010 Sep;87(3):338-44.

Di Gianvincenzo P, Marradi M, Martínez-Ávila OM, Bedoya LM, Alcamí J, Penadés S. Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents. Bioorg Med Chem Lett. 2010 May 1;20(9):2718-21.

Bedoya LM, Abad MJ, Sánchez-Palomino S, Alcamí J, Bermejo P. Ellagitannins from Tuberaria lignosa as entry inhibitors of HIV. Phytomedicine. 2010 Jan;17(1):69-74.

Martínez-Ávila O, Bedoya LM, Marradi M, Clavel C, Alcamí J, Penadés S. Multivalent manno-glyconanoparticles inhibit DC-SIGN-mediated HIV-1 trans-infection of human T cells. Chembiochem. 2009 Jul 20;10(11):1806-9.

Bedoya LM, Márquez N, Martínez N, Gutiérrez-Eisman S, Álvarez A, Calzado MA, et al. SJ23B, a jatrophane diterpene activates classical PKCs and displays strong activity against HIV in vitro. Biochem Pharmacol. 2009 Mar 15;77(6):965-78.

Bedoya LM, Álvarez A, Bermejo M, González N, Beltrán M, Sánchez-Palomino S, et al. Guatemalan plants extracts as virucides against HIV-1 infection. Phytomedicine. 2008 Jun;15(6-7):520-4.

Bedoya LM, del Olmo E, Sancho R, Barboza B, Beltrán M, García-Cadenas AE, et al. Anti-HIV activity of stilbene-related heterocyclic compounds. Bioorg Med Chem Lett. 2006 Aug 1;16(15):4075-9.

Bedoya LM, Beltrán M, Sancho R, Olmedo DA, Sánchez-Palomino S, del Olmo E, et al. 4-Phenylcoumarins as HIV transcription inhibitors. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4447-50.

Márquez N, Sancho R, Bedoya LM, Alcamí J, López-Pérez JL, Feliciano AS, et al. Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway. Antiviral Res. 2005 Jun;66(2-3):137-45.

Sancho R, Medarde M, Sánchez-Palomino S, Madrigal BM, Alcamí J, Muñoz E, et al. Anti-HIV activity of some synthetic lignanolides and intermediates. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4483-6.

Sancho R, Márquez N, Gómez-Gonzalo M, Calzado MA, Bettoni G, Coiras MT, et al. Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway. J Biol Chem. 2004 Sep 3;279(36):37349-59.

Bermejo M, Sánchez-Palomino S, Usán L, Alcamí J. Dynamics of HIV replication in lymphocytes and the efficacy of protease inhibitors. J Med Virol. 2004 Aug;73(4):502-7.

Rullas J, Bermejo M, García-Pérez J, Beltán M, González N, Hezareh M, et al. Prostratin induces HIV activation and downregulates HIV receptors in peripheral blood lymphocytes. Antivir Ther. 2004 Aug;9(4):545-54.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

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